Spider-Man 4 Casting Update: A Powerful Female Villain Joins the MCU

The upcoming Spider-Man 4 is shaping up to be a game-changer for the MCU, with fresh casting details hinting at a major shift in the franchise. Tom Holland and Zendaya are set to return, but the latest reports reveal that Marvel is introducing its first female villain in an MCU Spider-Man movie.
With director Destin Daniel Cretton leading the project and rumors of multiple villains, the casting of this new antagonist could significantly impact Peter Parker’s next adventure.
Spider-Man 4’s Female Villain: Who Could It Be? Industry insider Daniel Richtman has revealed that Spider-Man 4 is looking for a “powerful and imposing” female villain between the ages of 30-50, with an actress who has a “strong and commanding screen presence.”
While the exact character is unknown, journalist Jeff Sneider dropped a cryptic hint, suggesting that an actress with the initials “SS” might already be in negotiations for the role.
Sarah Snook as the Villain?
One name that immediately fits both the description and the initials is Succession star Sarah Snook. Snook has previously worked with Destin Daniel Cretton on The Glass Castle, making a reunion likely.
Snook’s ability to portray complex, commanding characters makes her a strong contender for a major MCU villain, but which character could she be playing?
Table of Contents
Possible Villains for Spider-Man 4
1. Silver Sable
A skilled mercenary and leader of the Wild Pack, Silver Sable has a morally gray stance in the comics, sometimes working with Spider-Man and sometimes opposing him. If Spider-Man 4 introduces a crime-driven story involving Kingpin or other street-level threats, Silver Sable could be a strong choice for an anti-heroic villain.
2. Madame Web (Cassandra Webb)
While Sony is developing its own Madame Web movie, the MCU could introduce its own take on the character. In the comics, Madame Web is a clairvoyant who can see the Spider-Verse and often guides Spider-Man. A darker reimagining could turn her into a more menacing force.
3. Chameleon (Gender-Swapped Version)
Chameleon is a master of disguise and deception, making him one of Spider-Man’s trickiest foes. If Marvel wants a unique twist, they could introduce a female version of Chameleon, played by Snook or another powerful actress.
4. Calypso
Calypso is a voodoo priestess who has been a dangerous villain in Spider-Man’s rogues’ gallery, often linked to Kraven the Hunter. With Kraven the Hunter already part of Sony’s universe, introducing Calypso in Spider-Man 4 could establish a strong supernatural presence in the MCU.
5. Queen Goblin (Ashley Kafka)
A newer villain, Queen Goblin, is a terrifying version of the Green Goblin mythos. A scientist at Ravencroft Institute, Ashley Kafka undergoes a transformation, becoming a formidable enemy for Spider-Man. If Marvel wants to introduce a Goblin-related threat without rehashing Norman Osborn, this could be the perfect option.
Two More Male Roles Are Being Cast
Along with the female villain, Spider-Man 4 is also casting two new male characters:
A “resourceful young man” in his early 20s – This could be a new ally for Peter Parker, potentially introducing Miles Morales or Harry Osborn into the MCU.
A “no-nonsense authority figure” in his 30s-50s – Described as someone who “sees the world in black and white” and is willing to cross lines to maintain order, this could be a corrupt law enforcement official, a government figure, or even an MCU version of J. Jonah Jameson’s right-hand enforcer.