As previously mentioned, Spider-Man 4 currently does not have a director attached, so Sam Raimi has as good a chance as any if he were wanting to take a stab at the MCU’s version of Marvel’s wall-crawler.
Raimi was previously going to make a Spider-Man 4 of his own with Tobey Maguire, but the project was ultimately cancelled as the director found it more and more creatively restricting to make films in Sony’s first super-powered universe.
The Doctor Strange in the Multiverse of Madness director said, now that some time has passed, “anything is possible” and he “[he’d] love to work with Tobey again,” if the opportunity were to present itself:
“I’ve come to realize after making Doctor Strange that anything is possible, really anything in the Marvel universe, any team-ups. I love Tobey. I love Kirsten Dunst. I think all things are possible. I don’t really have a story or a plan. I don’t know if Marvel would be interested in that right now. I don’t know what their thoughts are about that. I haven’t really pursued that. But it sounds beautiful. Even if it wasn’t a ‘Spider-Man’ movie, I’d love to work with Tobey again, in a different role.”
As for working on Tom Holland’s version of the character, he previously told Los Angeles Times after seeing No Way Home, “If I made a Spider-Man movie, it would probably have to be with Tobey or he’d break my neck:”
“I loved ‘No Way Home.’ I thought it was a complete audience thrill ride. The crowd I was with were ooh-ing and ahh-ing, and it had a great heart to it. It was great seeing my old friends again. I love Spider-Man. And I love Tom Holland in the role. [But] if I made a ‘Spider-Man’ movie, it would probably have to be with Tobey or he’d break my neck.”
As of May 2022, Raimi “[didn’t] have any plans to make Spider-Man 4” and had not “pursued that:”
“I currently don’t have any plans to make ‘Spider-Man 4.’ And they’re so successful with the new ‘Spider-Man’ series that I don’t know if that’s gonna happen or not. I haven’t pursued that.”